1,4-Dioxane hydrochloride → HCID 49848418, compound

Participants

Reaction Conditions

Reaction Steps

110 mg of 6-(4-tert-butoxycarbonyl-1,4-diazepan-1-ylsulfonyl)-1-methoxyisoquinoline was dissolved in 2 mL of 1,4-dioxane and 1.5 mL of water. 4 mL of a 4 M hydrochloric acid-dioxane solution was added dropwise thereto, and the mixture was then stirred at 90° C. for 16 hours. After the completion of reaction, the reaction solvent was distilled off. The obtained residue was dissolved in 5 mL of methanol, and 5 mL of ethyl acetate was then added with vigorous stirring. The deposited white crystal was collected by filtration and dried under reduced pressure to obtain 64 mg of the compound of interest as a white crystal (72%).

Provenance & Evidence