HCID 71041830, compound → HCID 71008841, compound

Participants

Reaction Steps

A solution of the product of Example 1h (tert-butyl (2R,6S,13aS,14aR,16aS,Z)-2-(3-fluorophenanthridin-6-yloxy)-14a-(1-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-6-ylcarbamate, 16.0 g, 20.6 mmol) in dichloromethane (100 mL) and 4 N HCl in dioxane (100 mL) was stirred at room temperature for 90 min and then evaporated under reduced pressure. The residue was partitioned between ethyl acetate (200 mL) and saturated aqueous sodium bicarbonate solution (200 mL) and the resulting solid isolated by filtration of the mixture through a medium porosity sintered glass funnel. The isolated solid was washed with water (2×150 mL) and dried under reduced pressure to provide the title compound (12.2 g, 88% yield).

Provenance & Evidence