Phosphorus oxychloride → HCID 86673690, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 8-fluorophenanthridin-6-ol (Example 2a, 0.15 g, 0.69 mmol) in phosphorus oxychloride (1.06 g, 0.65 mL, 6.9 mmol) was added dimethylformamide (5 mg, 5 μL), and the reaction mixture was warmed to 80° C. and stirred under nitrogen for 3 h. The reaction mixture was cooled to room temperature and evaporated under reduced pressure. The residue was triturated with hexane, and the resulting solid isolated by vacuum filtration, washed with water, and dried to provide the title compound (0.15 g, 95% yield) which was used without additional purification.

Provenance & Evidence