HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-chloro-7-(1-methylcyclopropyl)-7H-imidazo[4,5-c]pyridazine → 4-[4'-(Ethylsulfonyl)-6-fluorobiphenyl-3-yl]-7-(1-methylcyclopropyl)-7H-imidazo[4,5-c]pyridazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-chloro-7-(1-methylcyclopropyl)-7H-imidazo[4,5-c]pyridazine | HCID 86723210 | — |
| Reactant | 2-(4'-(Ethylsulfonyl)-6-fluoro-[1,1'-biphenyl]-3-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane | HCID 86723211 | — |
| Product | 4-[4'-(Ethylsulfonyl)-6-fluorobiphenyl-3-yl]-7-(1-methylcyclopropyl)-7H-imidazo[4,5-c]pyridazine | HCID 86723209 | 32% |
Reaction Steps
Prepared according to the method described for Example 26 using 4-chloro-7-(1-methylcyclopropyl)-7H-imidazo[4,5-c]pyridazine (Preparation 97) and 2-(4′-ethylsulfonyl-6-fluorobiphenyl-3-yl)-4,4,5,5-tetramethyl[1,3,2]dioxaborolane (Preparation 48) to afford the title compound as an off white solid in 32% yield, 20 mg
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08952008B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-85a664d895b54808ac142fd6f2d799e5 |
| Source note | uspto-grants-2015_02 |