HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-chloro-7-ethyl-7H-imidazo(4,5-c)pyridazine → 7-Ethyl-4-(4'-(ethylsulfonyl)-2',6-dimethoxy-[1,1'-biphenyl]-3-yl)-7H-imidazo[4,5-c]pyridazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-chloro-7-ethyl-7H-imidazo(4,5-c)pyridazine | HCID 55296765 | — |
| Reactant | 2-(4'-(Ethylsulfonyl)-2',6-dimethoxy-[1,1'-biphenyl]-3-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane | HCID 90217760 | — |
| Product | 7-Ethyl-4-(4'-(ethylsulfonyl)-2',6-dimethoxy-[1,1'-biphenyl]-3-yl)-7H-imidazo[4,5-c]pyridazine | HCID 90217933 | 13% |
Reaction Steps
Prepared according to the method described for Example 45 using 2-(4′-(Ethylsulfonyl)-2′,6-dimethoxy-[1,1′-biphenyl]-3-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (Preparation 59) and 4-chloro-7-ethyl-7H-imidazo[4,5-c]pyridazine (Preparation 8) to afford the title compound as an off white solid in 13% yield, 14.7 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08952008B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-04205bd5c816489f9d6b5f178141391b |
| Source note | uspto-grants-2015_02 |