HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1845998Generated: November 2, 2026
Ammonium Hydroxide → 3,5-Dichloro-1,4-dihydropyridazin-4-imine
https://huagongshe.com/reaction/1845998
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | 3,4,5-Trichloropyridazine | HCID 70111 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3,5-Dichloro-1,4-dihydropyridazin-4-imine | HCID 6403201 | 36% |
Reaction Steps
A mixture of 3,4,5-trichloropyridazine (Preparation 3, 500 mg, 2.73 mmole) in EtOH (5.5 mL) and NH4OH (5.5 mL) was heated under microwave irradiation 120° C. for 25 minutes. Concentration under reduced pressure and purification via silica gel column chromatography eluting with acetone:dichloromethane (0-15% acetone), provided the title product in 36% yield, 163 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08952008B2 |
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| Source dataset | uspto-grants-2015_02 |
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| ORD ID | ord-684ad457d66744869237a591806839a4 |
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| Source note | uspto-grants-2015_02 |
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