反应详情

温度

130 °C

A mixture of 5-chloro-N3-isopropylpyridazine-3,4-diamine (Preparation 5, 1020 mg, 5.47 mmol) in triethyl orthoformate (9 mL) was heated at 130° C. for 80 minutes. The solvent was removed in vacuo and the residue dissolved in MeOH/DCM and purified by silica gel column chromatography eluting with EtOAc:heptane 0-63% to provide the titled product as a white solid in 76% yield, 816 mg.

1. customThe solvent was removed in vacuo
2. dissolutionthe residue dissolved in MeOH/DCM
3. custompurified by silica gel column chromatography
4. washeluting with EtOAc