反应详情

温度

150 °C

3,5-Dichloropyridazin-4-amine (Preparation 4, 1 g, 6.09 mmol) was added to cyclopentylamine (3.0 mL, 30.41 mmol) and water (1 mL) in a stainless steel sealed container. The mixture was heated for 16 hours at 150° C. The reaction mixture was cooled to room temperature then evaporated in vacuo. The residue was purified by silica gel column chromatography eluting with EtOAc to afford the title compound as yellow solid in 90% yield, 1.17 g.

1. temperatureThe reaction mixture was cooled to room temperature
2. customthen evaporated in vacuo
3. customThe residue was purified by silica gel column chromatography
4. washeluting with EtOAc