2-Bromobenzoic acid → 2-Bromo-5-(chlorosulfonyl)benzoic acid

Participants

Reaction Conditions

Reaction Steps

2-Bromobenzoic acid (10.2 g, 50.8 mmol) was added in several portions to chlorosulfonic acid (50 mL) at 0° C. and the resulting solution held at this temperature for 15 minutes. The mixture was then heated at 115° C. for 16 hours. The reaction mixture was cooled to room temperature and was cautiously added drop-wise onto ice. The resulting suspension was allowed to reach room temperature and filtered. The solid was dried under vacuum at 40° C. for 16 hours. The title compound was obtained as a beige solid 85% yield, 12.8 g.

Provenance & Evidence