反应详情

1-Bromo-2-(difluoromethyl)-4-fluorobenzene (Preparation 50, 772 mg, 3.43 mmol) and sodium ethanethiolate (352.7 mg, 3.77 mmol) in DMSO (5 mL) was heated at 50° C. for 18 hours. On cooling, water (70 mL) was added to the reaction mixture, the product was extracted with EtOAc (20 mL×3). The combined organic layers were concentrated to give the crude product, which was purified by silica gel column chromatography eluting with heptane to afford the title compound as a colourless oil (260 mg, 28%).

1. temperatureOn cooling
2. extractionthe product was extracted with EtOAc (20 mL×3)
3. concentrationThe combined organic layers were concentrated
4. customto give the crude product, which
5. customwas purified by silica gel column chromatography
6. washeluting with heptane