Triethylamine → HCID 86723266, compound

Participants

Reaction Steps

To 2-bromo-5-(ethylsulfonyl)benzamide (Preparation 74, 2.20 g, 7.53 mmol) in THF (50 mL) with triethylamine (1.57 mL, 11.3 mmol) was added trifluoroacetic anhydride (1.26 mg, 9.04 mmol) dropwise under nitrogen. The reaction was left to stir for 16 hours, before dilution with EtOAc (100 mL) and washing with sodium bicarbonate solution (saturated 100 mL), HCl (1M, 100 mL) and brine (100 mL). The organic phase was dried over MgSO4 and the solvent removed under reduced pressure to give the title compound as a colourless solid in 80% yield, 1.64 g.

Provenance & Evidence