反应详情

A solution of 3-chloro-4-fluorobenzene boronic acid (4 g, 22.8 mmol) and naphthalene-1,8-diamine (3.62 g, 22.9 mol) in anhydrous toluene (80 mL) was heated to reflux for 4 hours. The reaction mixture was cooled to room temperature, then concentrated in vacuo. The residue was trituated with hexane to afford the title compound as a grey solid in 88% yield, 6 g.

1. temperatureto reflux for 4 hours
2. concentrationconcentrated in vacuo