1,3-Dibromo-5,5-dimethylhydantoin → HCID 86723272, compound

HRID 1846051Notes

Reaction equation

HRID 1846051 reaction equation
[CH:1]1([N:4]2[C:8]3[N:9]=[N:10][CH:11]=[C:12]([C:13]4[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=4)[C:7]=3[N:6]=[CH:5]2)[CH2:3][CH2:2]1.[Br:20]N1C(C)(C)C(=O)N(Br)C1=O>>[Br:20][C:15]1[CH:14]=[C:13]([C:12]2[C:7]3[N:6]=[CH:5][N:4]([CH:1]4[CH2:3][CH2:2]4)[C:8]=3[N:9]=[N:10][CH:11]=2)[CH:18]=[CH:17][C:16]=1[F:19]

Participants

3

Reactant 2

HCID 64791,3-Dibromo-5,5-dimethylhydantoinHCID 86723273HCID 86723273, compound

Product 1

HCID 86723272HCID 86723272, compoundYield 25%

Procedure

This was prepared by a Method analogous to that as described above for Preparation 87 using 7-cyclopropyl-4-(4-fluorophenyl)-7H-imidazo[4,5-c]pyridazine (Preparation 93, 450 mg, 1.77 mmol) and 1,3-dibromo-5,5-dimethylhydantoin (253.3 mg, 0.885 mmol) to afford the title compound as a white solid in 25% yield, 500 mg.

Workup

  1. customThis was prepared by a Method analogous to

Sources & evidence

ORD record
ord-fa8b9c614841441888138e0248903407
Source dataset
uspto-grants-2015_02
Patent number
US08952008B2

Reaction notes

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