反应详情

A mixture of 5-chloro-N-3-cyclopropylpyridazine-3,4-diamine (Preparation 90, 10.0 g, 54 mmol) and triethylorthoformate (120 mL) were heated to reflux for 3 hours. The reaction mixture was concentrated in vacuo and the residue was purified by silica gel column chromatography eluting with CH2Cl2:MeOH 98:2 to afford the title compound as a brown solid in 48% yield, 5 g.

1. temperaturewere heated
2. temperatureto reflux for 3 hours
3. concentrationThe reaction mixture was concentrated in vacuo
4. customthe residue was purified by silica gel column chromatography
5. washeluting with CH2Cl2:MeOH 98:2