1,3-Diiodo-5,5-dimethylimidazolidine-2,4-dione → HCID 90217534, compound

HRID 1846057Notes

Reaction equation

HRID 1846057 reaction equation
[CH:1]1([N:4]2[C:8]3[N:9]=[N:10][CH:11]=[C:12]([C:13]4[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=4)[C:7]=3[N:6]=[CH:5]2)[CH2:3][CH2:2]1.[I:20]N1C(C)(C)C(=O)N(I)C1=O>>[I:20][C:15]1[CH:14]=[C:13]([C:12]2[C:7]3[N:6]=[CH:5][N:4]([CH:1]4[CH2:3][CH2:2]4)[C:8]=3[N:9]=[N:10][CH:11]=2)[CH:18]=[CH:17][C:16]=1[F:19]

Participants

3

Reactant 2

HCID 2005341,3-Diiodo-5,5-dimethylimidazolidine-2,4-dioneHCID 86723273HCID 86723273, compound

Product 1

HCID 90217534HCID 90217534, compoundYield 79%

Procedure

Prepared by a Method analogous to that as described above for Preparation 87 using 7-cyclopropyl-4-(4-fluorophenyl)-7H-imidazo[4,5-c]pyridazine (Preparation 93) and 1,3-diiodo-5,5-dimethylhydantoin to afford the title compound in 79% yield.

Workup

  1. customPrepared by a Method analogous to

Sources & evidence

ORD record
ord-973684008c264e1185eab0ff1830df13
Source dataset
uspto-grants-2015_02
Patent number
US08952008B2

Reaction notes

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