反应详情

温度

140 °C

A mixture of 5-chloro-N3-propylpyridazine-3,4-diamine (Preparation 100, 800 mg, 4.30 mmol) and triethyl orthoformate (10 mL) was heated at 140° C. for 4 hours. After evaporation in vacuo, the crude residue was purified by silica gel column chromatography eluting with CH2Cl2:MeOH 98:2 to afford the title compound as a brown solid in 47% yield, 400 mg.

1. customAfter evaporation in vacuo
2. customthe crude residue was purified by silica gel column chromatography
3. washeluting with CH2Cl2:MeOH 98:2