HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 2-(2,2-Difluoroethyl)oxy-5-nitro-benzoate → Ethyl 5-amino-2-(2,2-difluoroethyl)oxy-benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 2-(2,2-Difluoroethyl)oxy-5-nitro-benzoate | HCID 86658666 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Ethyl 5-amino-2-(2,2-difluoroethyl)oxy-benzoate | HCID 58483394 | — |
Reaction Steps
A mixture of ethyl 2-(2,2-difluoroethyl)oxy-5-nitro-benzoate (600 mg, 2.18 mmol) and 80 mg 10% Pd/C in 30 mL MeOH was stirred for 6.5 h under an atmosphere of hydrogen (3 bar). After filtration and concentration i. vac. the subtitle compound was obtained. Yield: 500 mg, (94%). MS [M+H]+=246; TLC: Rf=0.2 (silica gel, DCM:EtOH 99:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08951999B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-d9171c87bed744ee98b6543814e83ab3 |
| Source note | uspto-grants-2015_02 |