1-Chloro-N,N-2-trimethylpropenylamine → HCID 52919088, compound

Participants

Reaction Steps

1-Chloro-N,N,2-trimethylpropenylamine (23 was added to a mixture of N-[4-methoxy-3-hydroxycarbonyl-phenyl]-2-chloro-5-(tert-butylcarbonylamino)methyl-benzamide (60.0 mg, 0.143 mmol, prepared from ethyl 5-amino-2-methoxy benzoate in analogy to step 5c and 5d) in 2.0 mL THF and it was stirred for 2 h. additional 80 μL of 1-chloro-N,N,2-trimethylpropenylamine were added and it was stirred for another 2 h. Then TEA (0.100 mL) and 2-amino-4-trifluormethyl-pyridine (23.2 mg, 0.143 mmol) were added and it was stirred overnight. The reaction mixture was concentrated and purified via prep. HPLC (method A) to furnish the title compound.

Provenance & Evidence