HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1846096Generated: November 3, 2026
N-[4-Methoxy-3-(4-bromophenyl)aminocarbonyl-phenyl]-2-chloro-5-(tert-butoxycarbonylamino)methyl-benzamide → N-[4-Methoxy-3-(4-bromophenyl)aminocarbonyl-phenyl]-2-chloro-5-aminomethyl-benzamide
https://huagongshe.com/reaction/1846096
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | N-[4-Methoxy-3-(4-bromophenyl)aminocarbonyl-phenyl]-2-chloro-5-(tert-butoxycarbonylamino)methyl-benzamide | HCID 67116272 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | N-[4-Methoxy-3-(4-bromophenyl)aminocarbonyl-phenyl]-2-chloro-5-aminomethyl-benzamide | HCID 67116388 | — |
Reaction Steps
A mixture of 2.66 g N-[4-methoxy-3-(4-bromophenyl)aminocarbonyl-phenyl]-2-chloro-5-(tert.butoxycarbonylamino)methyl-benzamide (4.51 mmol) 25 mL 4M HCl in dioxane and 50 mL dioxane was stirred for 2 h at rt and 60 min at 50° C. and concentrated i.vac. to furnish the subtitle compound. Yield: (quantitative). MS [M+H]+=488 (Br/Cl-isotope pattern).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08951999B2 |
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| Source dataset | uspto-grants-2015_02 |
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| ORD ID | ord-2d845f58350c44959165526c96fb560a |
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| Source note | uspto-grants-2015_02 |
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