HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridoxal 5'-phosphate monohydrate → N-(4-Bromophenyl)-2-(4-methyl-piperidin-1-yl)-5-amino-benzoic acid amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridoxal 5'-phosphate monohydrate | HCID 38882 | — |
| Reactant | N-(4-bromophenyl)-2-(4-methyl-piperidin-1-yl)-5-nitro-benzoic acid amide | HCID 67116648 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-(4-Bromophenyl)-2-(4-methyl-piperidin-1-yl)-5-amino-benzoic acid amide | HCID 67116511 | — |
Reaction Steps
Prepared analogously to Example 4b from N-(4-bromophenyl)-2-(4-methyl-piperidin-1-yl)-5-nitro-benzoic acid amide and Ra-Ni in THF. Yield: (quantitative). MS [M+H]+=388 (Br-isotope pattern); Rt=1.36 min (Method MC-1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08951999B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-21e6ea9ec1f24652bd1c712c171afbce |
| Source note | uspto-grants-2015_02 |