HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 58483401, compound → HCID 58483440, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 58483401 | HCID 58483401 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Ammonia | HCID 222 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 58483440 | HCID 58483440 | — |
Reaction Steps
A mixture of 5-cyano-2-trifluoromethyl-benzoic acid ethyl ester (250 mg; 1.03 mmol) and 100 mg Ra-Ni in 20 mL NH3 in MeOH was stirred for 17 h under an atmosphere of hydrogen (3 bar). After filtration and concentration i.vac. the subtitle compound was obtained. Yield: 250 mg (98%); MS: [m+H]+=248; TLC (silica gel; DCM/EtOH 9/1) Rf=0.28.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08951999B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-0d2fdfd8424a4dd59b1f6466aeea995e |
| Source note | uspto-grants-2015_02 |