Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) → HCID 52919853, compound

Participants

Reaction Steps

A mixture of 5-(tert-butylcarbonylamino)methyl-2-trifluoromethyl-benzoic acid (50 mg; 0.13 mmol) HATU (53.8 mg, 0.14 mmol) and TEA (0.066 mL 0.47 mmol) in 2 mL THF was stirred for 15 min at rt. 5-Amino-N-(4-bromo-phenyl)-2-(2,2-difluoro-ethoxy)-benzamide (40.8 mg; 0.13 mmol) was added and it was stirred over night. The solvent was evaporated and the residue was purified by prep HPLC.

Provenance & Evidence