Sulfuric Acid → HCID 86658673, compound

HRID 1846109Notes

Reaction equation

HRID 1846109 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([Cl:11])[C:3]=1[C:4]([OH:6])=[O:5].OS(O)(=O)=O.O[CH2:18][NH:19][C:20](=[O:25])[C:21]([F:24])([F:23])[F:22]>O>[F:22][C:21]([F:24])([F:23])[C:20]([NH:19][CH2:18][C:8]1[C:7]([Cl:11])=[C:3]([C:2]([Cl:1])=[CH:10][CH:9]=1)[C:4]([OH:6])=[O:5])=[O:25]

Participants

5

Reactant 3

HCID 1118Sulfuric AcidHCID 57582,6-Dichlorobenzoic acidHCID 30849312,2,2-Trifluoro-N-(hydroxymethyl)acetamide

Product 1

HCID 86658673HCID 86658673, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Step i): A mixture of 2,6-dichlorobenzoic acid (4 g; 20.94 mmol), conc. H2SO4 (50 mL) and N-(hydroxymethyl)trifluoroacetamide (2.996 g; 20.94 mmol) was stirred at rt overnight. The mixture was diluted with 500 mL crushed ice and 200 mL H2O, the precipitate was filtered and dried to give crude 3-(trifluoromethylcarbonylamino-methyl)-2,6-dichloro-benzoic acid.

Workup

  1. additionThe mixture was diluted with 500 mL
  2. filtrationthe precipitate was filtered
  3. customdried

Sources & evidence

ORD record
ord-c3456666ac8d4c4690395d90cae3774e
Source dataset
uspto-grants-2015_02
Patent number
US08951999B2

Reaction notes

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