HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromoaniline → N-[3,4-Difluoro-5-(4-bromophenyl)aminocarbonyl-phenyl]-2-chloro-5-(tert-butylcarbonylamino)methyl-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromoaniline | HCID 7807 | — |
| Reactant | 5-{2-Chloro-5-[(tert-butylcarbonylamino)-methyl]-benzoylamino}-2,3-difluoro-benzoic acid | HCID 67116429 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-[3,4-Difluoro-5-(4-bromophenyl)aminocarbonyl-phenyl]-2-chloro-5-(tert-butylcarbonylamino)methyl-benzamide | HCID 52920323 | — |
Reaction Steps
Prepared analogously to example 2f with 5-{2-Chloro-5-[(tert-butylcarbonylamino)-methyl]-benzoylamino}-2,3-difluoro-benzoic acid (0.29 g; 0.68 mmol); 4-bromoaniline (0.117 g; 0.68 mmol); PPA (0.523 mL; 0.89 mmol; 50% solution in DMF) and TEA (0.237 mL; 1.71 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08951999B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-ac2a4d3128e3455bbef1e9f9c8382beb |
| Source note | uspto-grants-2015_02 |