HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridoxal 5'-phosphate monohydrate → 5-Amino-N-(4-bromo-phenyl)-2-methyl-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridoxal 5'-phosphate monohydrate | HCID 38882 | — |
| Reactant | N-(4-bromo-phenyl)-2-methyl-5-nitro-benzamide | HCID 47364174 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Dichloromethane ethanol | HCID 21584144 | — |
| Product | 5-Amino-N-(4-bromo-phenyl)-2-methyl-benzamide | HCID 58483474 | — |
Reaction Steps
Prepared analogously to example 2e with N-(4-bromo-phenyl)-2-methyl-5-nitro-benzamide (0.18 g; 0.54 mmol) and Ra-Ni (20 mg), 3 bar H2. Yield: 0.14 g (85%) MS: [m+H]+=305; HPLC Rt=1.2 min (Method MC-1); TLC (silica gel; DCM/EtOH 95/5) Rf=0.3
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08951999B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-0835278b40b84074b0ac4e22a171e192 |
| Source note | uspto-grants-2015_02 |