HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) → N-[4-Methyl-3-(4-bromophenyl)aminocarbonyl-phenyl]-2-chloro-5-(tert-butylcarbonylamino)methyl-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | 2-Chloro-5-[(2,2-dimethylpropanamido)methyl]benzoic acid | HCID 58483208 | — |
| Reactant | 5-Amino-N-(4-bromo-phenyl)-2-methyl-benzamide | HCID 58483474 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-[4-Methyl-3-(4-bromophenyl)aminocarbonyl-phenyl]-2-chloro-5-(tert-butylcarbonylamino)methyl-benzamide | HCID 52920324 | — |
Reaction Steps
Prepared analogously to example 7 with 5-(tert-butylcarbonylamino)methyl-2-chloro benzoic acid (50 mg; 0.19 mmol); 5-amino-N-(4-bromo-phenyl)-2-methyl-benzamide (57 mg; 0.19 mmol); HATU (78 mg; 0.2 mmol) in TEA (77 μL; 0.56 mmol) and 5 mL THF.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08951999B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-c0f3f663c64d4d63bbcad4fcb0a2710e |
| Source note | uspto-grants-2015_02 |