HuagongsheHuagongshe Chemistry Print Report · For research reference only
4,6-Dibromo-2,3-bis(methylsulfanyl)-1H-indole → 5-Amino-2-(4-trifluoromethyl-piperidin-1-yl)-N-cyclopropylmethylbenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4,6-Dibromo-2,3-bis(methylsulfanyl)-1H-indole | HCID 14185853 | — |
| Reactant | 5-nitro-2-(4-trifluoromethyl-piperidin-yl)-N-cyclopropylmethylbenzamide | HCID 58483470 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 5-Amino-2-(4-trifluoromethyl-piperidin-1-yl)-N-cyclopropylmethylbenzamide | HCID 58483389 | — |
Reaction Steps
Prepared analogously to example 42c with 5-nitro-2-(4-trifluoromethyl-piperidin-yl)-N-cyclopropylmethylbenzamide (370 mg; 1 mmol) and Pd/C 10%/H2 (60 mg/3 bar) in 60 mL THF. Yield: quantitative; MS: [M+H]+=342; HPLC: Rt=1.68 min (Method MC-6)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08951999B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-e2e561ec8ee94e03ba7be0473e177f77 |
| Source note | uspto-grants-2015_02 |