HuagongsheHuagongshe Chemistry Print Report · For research reference only
O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate → N-[4-Methoxyethoxy-3-(4-bromphenyl)aminocarbonyl-phenyl]-2-chloro-5-(2,2,2-trifluoro-1-methyl-ethyl)carbonylaminomethyl-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 3,3,3-Trifluoro-2-methylpropanoic acid | HCID 11320987 | — |
| Reactant | N-[4-methoxyethoxy-3-(4-bromphenyl)aminocarbonyl-phenyl]-2-chloro-5-aminomethyl-benzamide | HCID 67116841 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-[4-Methoxyethoxy-3-(4-bromphenyl)aminocarbonyl-phenyl]-2-chloro-5-(2,2,2-trifluoro-1-methyl-ethyl)carbonylaminomethyl-benzamide | HCID 52920451 | — |
Reaction Steps
Prepared analogously to example 53d with 3,3,3-trifluoro-2-methyl-propionic acid (10 mg; 0.07 mmol); N-[4-methoxyethoxy-3-(4-bromphenyl)aminocarbonyl-phenyl]-2-chloro-5-aminomethyl-benzamide (32 mg; 0.06 mmol); TBTU (21 mg; 0.07 mmol) in TEA (25 μL; 0.18 mmol) and 3 mL DMF.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08951999B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-eef2551bb23c450bbe5fcb053750557a |
| Source note | uspto-grants-2015_02 |