HuagongsheHuagongshe Chemistry Print Report · For research reference only
4,6-Dibromo-2,3-bis(methylsulfanyl)-1H-indole → Ethyl 5-(aminomethyl)-2-chlorobenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4,6-Dibromo-2,3-bis(methylsulfanyl)-1H-indole | HCID 14185853 | — |
| Reactant | 5-(Aminomethyl)-2-chlorobenzoic acid | HCID 20378356 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethyl 5-(aminomethyl)-2-chlorobenzoate | HCID 53418808 | — |
Reaction Steps
Prepared analogously to example 42d with 5-aminomethyl-2-chlorobenzoic acid (2 g; 9.01 mmol) in 20 mL HCl in EtOH. Yield: 2.38 g (90%); MS: [M+H]+=214 (Cl isotope pattern); HPLC: Rt=1.20 min (Method MC-6)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08951999B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-1e63a685749a4ab8af3293cb79f81ab2 |
| Source note | uspto-grants-2015_02 |