HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloro-5-fluoroaniline → N-(3-chloro-5-fluoro-phenyl)-2-(2,2-difluoroethoxy)-5-nitro-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloro-5-fluoroaniline | HCID 2734838 | — |
| Reactant | 4,6-Dibromo-2,3-bis(methylsulfanyl)-1H-indole | HCID 14185853 | — |
| Reactant | 2-(2,2-Difluoroethyl)oxy-5-nitro-nicotinic acid chloride | HCID 58483419 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-(3-chloro-5-fluoro-phenyl)-2-(2,2-difluoroethoxy)-5-nitro-nicotinamide | HCID 58483304 | — |
Reaction Steps
Prepared analogously to example 6c with 2-(2,2-difluoro-ethoxy)-5-nitro-nicotinic acid chloride (prepared analogously to 6b) (179 mg; 0.67 mmol); 3-chloro-5-fluoroaniline (98 mg; 0.67 mmol) and TEA (112 μL; 0.81 mmol) in 5 mL DCM. Yield: 230 mg (91%); MS: [m+H]+=376 (Cl isotope pattern); HPLC: Rt=2.35 min (Method MC-6)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08951999B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-74b038ca8b8e4d5aa60bd40f58ab07ea |
| Source note | uspto-grants-2015_02 |