HCID 90460626, compound → HCID 90460678, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (R/S) (5-(3-(2-methoxyethoxy)-5-(trifluoromethyl)phenyl)-3-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl)methanol (320 mg, 0.77 mmol, 1.00 equiv) and MnO2 (672 mg, 7.73 mmol, 10.01 equiv) in dichloromethane (40 mL) was stirred at 40° C. for 3 h. The reaction mixture of cooled to room temperature and the solid material was removed by filtration. The filtrate was concentrated under vacuum to give 300 mg (94%) of (R/S) 5-(3-(2-methoxyethoxy)-5-(trifluoromethyl)phenyl)-3-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole-4-carbaldehyde as a yellow oil. LCMS (method D, ESI): RT=1.61 min, m/z=413.0 [M+H]+.

Provenance & Evidence