HCID 90460282, compound → HCID 90460195, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (R/S) (4-(3-(2-methoxyethoxy)-5-(trifluoromethyl)phenyl)-5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)methanol (70 mg, 0.17 mmol, 1.00 equiv) and MnO2 (147 mg, 1.69 mmol, 10.01 equiv) in dichloromethane (20 mL) was stirred at 40° C. for 1 h. The solid was removed by filtration. The filtrate was concentrated under vacuum to give 87 mg of crude (R/S) 4-(3-(2-methoxyethoxy)-5-(trifluoromethyl)phenyl)-5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole-3-carbaldehyde as a brown oil.

Provenance & Evidence