反应详情

温度

130 °C

1H-Benzo[d][1,3]oxazine-2,4-dione (A) (3.26 g, 20.0 mmol) and 4-bromo-aniline (H) (3.23 g, 18.8 mmol) were mixed together as a neat mixture (both solids), and the reaction mixture was stirred at 130° C. for 4 hours, and then cooled to room temperature. The crude compound was purified by the Simpliflash system (20% ethyl acetate in hexanes as eluent) to give 2-amino-N-(4-bromo-phenyl)-benzamide (J) as white solid. Yield: 4.35 g (75%).

1. temperaturecooled to room temperature
2. customThe crude compound was purified by the Simpliflash system (20% ethyl acetate in hexanes as eluent)