Oxalyl chloride → Acetic acid 4-chlorocarbonyl-2,6-dimethyl-phenyl ester

Participants

Reaction Steps

To a solution of 4-acetoxy-3,5-dimethylbenzoic acid (2.08 g, 10.0 mmol) in anhydrous dichloromethane (40 mL) were sequentially added oxalyl chloride (3.81 g, 30.0 mmol) and anhydrous DMF (5 drops). The reaction mixture was stirred at room temperature for 6 hours. Solvent and excess oxalyl chloride were evaporated under reduced pressure and the residue was dried under vacuum to give acetic acid 4-chlorocarbonyl-2,6-dimethylphenyl ester (3) as an orange solid. Yield: 2.32 g (100%).

Provenance & Evidence