Pyridine → HCID 86659803, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 2-amino-4-methanesulfonyl-benzoic acid (1.00 g, 4.64 mmol) in acetonitrile (15 mL) at 55° C. were simultaneously added pyridine (0.75 mL, 9.3 mmol) and a solution of triphosgene (0.455 g, 1.53 mmol) in dichloromethane (5 mL). The resulting mixture was stirred at 55° C. for 2 hours and the solvent was removed using a rotary evaporator. The residue was diluted with water (50 mL) and the precipitate was filtered, and air dried to provide 7-methanesulfonyl-1H-benzo[d][1,3]oxazine-2,4-dione. Yield: 0.98 g (82%).

Provenance & Evidence