Methanesulfonyl chloride → HCID 131732432, compound

Participants

Reaction Steps

TEA (0.24 mL, 1.70 mmol) followed by methanesulfonyl chloride (0.13 mL, 1.70 mmol) were added to a solution of 3-(4-aminophenyl)-2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)quinazolin-4(3H)-one (0.230 g, 0.57 mmol) in CH2Cl2 (10 mL). After stirring for 6 hours at room temperature, the mixture was concentrated in vacuo. Purification by flash chromatography on silica gel, eluting with 2% to 8% MeOH in CH2Cl2, afforded 2-(2,6-dimethyl-4-(3-(4-(N-(methylsulfonyl)methylsulfonamido) phenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)phenoxy)ethyl methanesulfonate (0.280 g, 77%).

Provenance & Evidence