Diethylamine → HCID 46841858, compound

Participants

Reaction Steps

Pd(OAc)2 (0.026 g, 0.12 mmol), DPPF (0.055 g, 0.10 mmol) and NaOtBu (0.049 g, 0.52 mmol) were added to a mixture of 2-(5-bromopyridin-3-yl)-3-(4-sec-butylphenyl)quinazolin-4(3H)-one (0.175 g, 0.40 mmol) and Et2NH (0.06 mL, 0.60 mmol) in toluene (2 mL). The mixture was microwaved at 90° C. and 300 W (max. power) with cooling for 3 hours, before being concentrated in vacuo. Purification by flash chromatography on silica gel, eluting with 5% to 60% EtOAc in heptane, plus further purification by flash chromatography on silica gel, eluting with 30% to 90% EtOAc in heptane, afforded the title compound as a white solid (0.010 g, 5%). 1H-NMR (300 MHz, DMSO-d6): δ8.20 (d, J=6.9 Hz, 1H), 7.84-7.98 (m, 3H), 7.77 (d, J=7.9 Hz, 1H), 7.55-7.68 (m, 1H), 7.26 (d, J=7.8 Hz, 2H), 7.08-7.20 (m, 2H), 6.80 (s, 1H), 3.06-3.23 (m, 4H), 2.51-2.65 (m, 1H), 1.35-1.60 (m, 2H), 1.08-1.20 (m, 3H), 0.81-1.00 (m, 6H), 0.62 (t, J=7.3 Hz, 3H). MS (APCI) m/z: 427 (M+H)+.

Provenance & Evidence