反应详情

(6-((tetrahydro-2H-pyran-2-yloxy)methyl)pyridin-3-yl)methanol (1.3 g, 6.0 mmol) was dissolved in CH2Cl2 (80 mL) and NMO (0.846 g, 7.2 mmol) and TPAP (0.210 g, 0.6 mmol) were added. After stirring at room temperature for 20 minutes, the reaction mixture was filtered through Celite®, and the filtrate was concentrated. Purification of the residue by flash chromatography on silica gel, eluting with 30% ethyl acetate/heptane to 75% ethyl acetate/heptane, afforded 6-((tetrahydro-2H-pyran-2-yloxy)methyl)nicotinaldehyde as a yellow oil (0.560 g, 42%).

1. filtrationthe reaction mixture was filtered through Celite®
2. concentrationthe filtrate was concentrated
3. customPurification of the residue by flash chromatography on silica gel
4. washeluting with 30% ethyl acetate/heptane to 75% ethyl acetate/heptane