Sodium Hydroxide → HCID 67454686, compound

Participants

Reaction Steps

N-(4-(2-(6-methylpyridin-3-yl)-4-oxoquinazolin-3(4H)-yl)phenyl)acetamide (0.130 g, 0.33 mmol) was refluxed in 2 N HCl for 1 hour. The mixture was cooled to room temperature and basified with 1 N NaOH, and extracted with CH2Cl2. The organics were washed with brine, dried (Na2SO4), filtered, and concentrated in vacuo, to afford 3-(4-aminophenyl)-2-(6-methylpyridin-3-yl)quinazolin-4(3H)-one (0.110 g, quantitative).

Provenance & Evidence