Isatoic Anhydride → HCID 67459390, compound

Participants

Reaction Conditions

Reaction Steps

Isatoic anhydride (0.393 g, 2.41 mmol) and 4-cyclopropylaniline (0.320 g, 2.41 mmol) were dissolved in DMF (5 mL) and heated at 135° C. for 5 hours. The reaction mixture was concentrated, and purified by silica gel chromatography, eluting with 30% ethyl acetate/heptane to 100% ethyl acetate, to afford 2-amino-N-(4-cyclopropylphenyl)benzamide as a white solid (0.342 g, 56%).

Provenance & Evidence