HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1846363Generated: November 3, 2026
tert-Butoxy bis(dimethylamino)methane → (E)-3-(4-Chlorophenyl)-2-(3-(2-(dimethylamino)vinyl)-4-nitrophenyl)quinazolin-4(3H)-one
https://huagongshe.com/reaction/1846363
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | tert-Butoxy bis(dimethylamino)methane | HCID 79885 | — |
| Reactant | HCID 67455493 | HCID 67455493 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (E)-3-(4-Chlorophenyl)-2-(3-(2-(dimethylamino)vinyl)-4-nitrophenyl)quinazolin-4(3H)-one | HCID 86659818 | 100.7% |
Reaction Steps
tert-butoxybis(dimethylamino)methane (0.47 mL, 2.30 mmol) was added to a solution of 3-(4-chlorophenyl)-2-(3-methyl-4-nitrophenyl)quinazolin-4(3H)-one (0.300 g, 0.76 mmol) in DMF (30 mL). After heating at 40° C. for 3.5 hours, concentration in vacuo afforded (E)-3-(4-Chlorophenyl)-2-(3-(2-(dimethylamino)vinyl)-4-nitrophenyl)quinazolin-4(3H)-one (0.342 g, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08952021B2 |
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| Source dataset | uspto-grants-2015_02 |
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| ORD ID | ord-7af2515edb834c8b9020292471130616 |
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| Source note | uspto-grants-2015_02 |
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