反应详情

3-(4-sec-butylphenyl)-2-(3,4-dinitrophenyl)quinazolin-4(3H)-one (0.240 g, 0.54 mmol) was dissolved in EtOH (20 mL) and flushed with N2 for 15 minutes. Pd/C (0.025 g, 10 wt %) was added, and stirred under 1 atmosphere of H2 overnight. After flushing with N2, the mixture was filtered through diatomaceous earth. The filtrate was concentrated and purified by flash chromatography on silica gel, eluting with 0% to 10% MeOH in EtOAc, to afford 3-(4-sec-butylphenyl)-2-(3,4-diaminophenyl)quinazolin-4(3H)-one (0.130 g, 62%).

1. customflushed with N2 for 15 minutes
2. additionPd/C (0.025 g, 10 wt %) was added
3. customAfter flushing with N2
4. filtrationthe mixture was filtered through diatomaceous earth
5. concentrationThe filtrate was concentrated
6. custompurified by flash chromatography on silica gel
7. washeluting with 0% to 10% MeOH in EtOAc