Acrolein dimer → [(1-Cyclopentyl-1H-tetrazol-5-yl)-(3,4-dihydro-2H-pyran-2-yl)-methyl]-(3-imidazol-1-yl-propyl)-amine

関与物質

役割	名称	HCID	仕込み量
反応物	Acrolein dimer	HCID 60994	—
反応物	Azidotrimethylsilane	HCID 78378	—
反応物	1H-Imidazole-1-propanamine	HCID 78736	—
反応物	Cyclopentyl Isocyanide	HCID 2734784	—
溶媒	Methanol	HCID 887	—
生成物	[(1-Cyclopentyl-1H-tetrazol-5-yl)-(3,4-dihydro-2H-pyran-2-yl)-methyl]-(3-imidazol-1-yl-propyl)-amine	HCID 25059135	—

反応手順

3-Imidazol-1-yl-propylamine (1 mmol) and 3,4-Dihydro-2H-pyran-2-carbaldehyde (1 mmol) were combined in methanol (2 ml, dry). After 2 hours Trimethylsilylazide (5 mmol) and Isocyano-cyclopentan (1 mmol) was added. The reaction was stirred at room temperature for 48 h. After evaporation of the solvent the residue was purified with chromatographic methods.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US07741354B2
出典データセット	uspto-grants-2010_06
ORD ID	ord-3e0f9a51eab2438f8ca1618be1899848
出典メモ	uspto-grants-2010_06