Benzene → HCID 90384693, compound

Participants

Reaction Conditions

Reaction Steps

Under an argon atmosphere, the compound 112 (2.33 g, 3.69 mmol) was dissolved in ethanol (20 mL), benzene (36 mL), and water (10 mL), the solution was added with 10% palladium-carbon (2.3 g), and aqueous hydrazine (64 v/v %, 25 mL), and the mixture was stirred at 85° C. for 16 hours. The reaction mixture was diluted with ethyl acetate, and filtered through Celite. The organic layer was washed with water, and saturated brine, dried over anhydrous sodium sulfate, and then concentrated. The obtained crude product was purified by silica gel column chromatography to give the title compound 113 (650 mg, 37%).

Provenance & Evidence