HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 6-(6-chloro-pyrimidin-4-yloxy)-4-methyl-3H-benzoxazol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4,6-Dichloropyrimidine | HCID 70943 | — |
| Reactant | 6-hydroxy-4-methylbenzo[d]oxazol-2(3H)-one | HCID 66978093 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-(6-chloro-pyrimidin-4-yloxy)-4-methyl-3H-benzoxazol-2-one | HCID 86663891 | — |
Reaction Steps
0.10 g (0.60 mmol) 6-hydroxy-4-methyl-3H-benzoxazol-2-one in 1.5 mL DMF were combined with 0.10 g (0.70 mmol) potassium carbonate and stirred for 15 min at RT. Then 0.10 g (0.60 mmol) 4,6-dichloropyrimidine were added to the reaction mixture and stirred overnight at RT. Then water was added and the precipitate formed was suction filtered, washed and dried i. vac.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08952014B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-07131b398064435881a0d3a6fe1e5e0c |
| Source note | uspto-grants-2015_02 |