4,6-Dichloropyrimidine → 6-(6-chloro-pyrimidin-4-ylamino)-4-methyl-3H-benzoxazol-2-one

Participants

Reaction Steps

400 mg (2.40 mmol) 6-amino-4-methyl-3H-benzoxazol-2-one, 400 mg (2.70 mmol) 4,6-dichloropyrimidine and 1.10 mL (8.00 mmol) TEA in 5 mL 1-butanol were stirred for 1 h at 100° C. After cooling to RT the reaction mixture was evaporated down and the residue was washed with water and saturated sodium hydrogen carbonate solution. The organic phase was dried on sodium sulphate, filtered and evaporated down.

Provenance & Evidence