4,6-Dichloropyrimidine → HCID 86663898, compound

Participants

Reaction Steps

500 mg (3.40 mmol) 4,6-dichloropyrimidine, 500 mg (3.40 mmol) 7-methyl-1H-indazol-5-ylamine and 1.30 mL (7.60 mmol) DIPEA were combined in 5.0 mL DMF and refluxed for 5 h. The reaction mixture was cooled to RT and evaporated down i.vac. The residue was taken up in EtOAc and extracted several times with saturated sodium chloride solution. The organic phases were combined, dried on magnesium sulphate, filtered and evaporated down. The residue was stirred with DIPE, suction filtered and dried i. vac.

Provenance & Evidence