反应详情

150 mg (0.700 mmol) 1,2,7-trimethyl-1H-benzimidazol-5-ylamine hydrochloride, 260 mg (0.800 mmol) 4,6-diiodopyrimidine, 0.300 mL (2.00 mmol) TEA and 5.0 mL 1-butanol were combined and stirred for 1 h at RT. The reaction mixture was evaporated down and the residue was extracted with DCM and 1N aqueous sodium hydroxide solution. The organic phase was dried on sodium sulphate, filtered and evaporated down.

1. customThe reaction mixture was evaporated down
2. extractionthe residue was extracted with DCM and 1N aqueous sodium hydroxide solution
3. customThe organic phase was dried on sodium sulphate
4. filtrationfiltered
5. customevaporated down