HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1846470Generated: November 1, 2026
Potassium Carbonate → 6-(6-chloropyrimidin-4-yloxy)-2-cyclopropyl-4-methyl-1H-benzo[d]imidazole
https://huagongshe.com/reaction/1846470
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4,6-Dichloropyrimidine | HCID 70943 | — |
| Reactant | 2-cyclopropyl-4-methyl-1H-benzo[d]imidazol-6-ol | HCID 66978175 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-(6-chloropyrimidin-4-yloxy)-2-cyclopropyl-4-methyl-1H-benzo[d]imidazole | HCID 86663915 | — |
Reaction Steps
90 mg (0.48 mmol) 2-cyclopropyl-4-methyl-1H-benzo[d]imidazol-6-ol and 77 mg (0.50 mmol) 4,6-dichloropyrimidine in 2.0 mL DMF were combined with 70 mg (0.50 mmol) potassium carbonate and stirred for 8 h at 50° C. Then ice water was added and the substance was extracted with ethyl acetate and concentrated by rotary evaporation i.vac.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08952014B2 |
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| Source dataset | uspto-grants-2015_02 |
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| ORD ID | ord-ba3817d0dbdd4efc92385480aebc5827 |
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| Source note | uspto-grants-2015_02 |
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