Sulfuryl chloride → 2-Chloro-4-methoxy-6-nitroaniline

Participants

Reaction Steps

20.0 g (118.94 mmol) 4-methoxy-2-nitroaniline and 10.0 mL sulphuryl chloride were placed in 300.0 mL acetic acid and stirred for 3 h at RT. The reaction mixture was poured onto water and the precipitate formed was suction filtered, washed and dried. The substance obtained was purified by chromatography. The fractions containing product were combined and evaporated down i.vac.

Provenance & Evidence